Fig. 1.

ANG II decreases the abundance of aquaporin (AQP)2 in the inner medulla (IM) and outer medulla (OM) of PKC-α knockout (PKC-α^−/−) mice but has no effect on AQP2 abundance in wild-type (WT) mice. A and B: protein obtained from the IM from WT (A) and PKC-α^−/− (B) animals probed with anti-AQP2 antibody. C and D: AQP2 abundance in the OM of WT (C) and PKC-α^−/− (D) mice. E and F: lack of change in AQP2 abundance in the cortices of WT (E) and PKC-α^−/− (F) mice. Top, representative Western blots from each group probed with AQP2; bottom, average densitometry.