Table 1.

Comparison of physiological parameters between WT and PKC-α^−/− mice after 7 days of subcutaneous infusion of ANG II

	WT Mice	WT Mice + ANG II	PKC-α−/− Mice	PKC-α−/− Mice + ANG II
Systolic blood pressure, mmHg	110 ± 5	147 ± 15*	119 ± 2	150 ± 2*
Urine output, μl/day	717 ± 149	1,430 ± 497	950 ± 182	2,800 ± 390*
Urine osmolality, mosM	3,748 ± 505	3,656 ± 502	3,018 ± 415	1,709 ± 220*
Urine urea, mM	2,075 ± 322	1,898 ± 291	1,480 ± 159	787 ± 77*
Water intake, ml/day	6.07 ± 0.7	4.06 ± 0.22	2.675 ± 0.38	7.59 ± 0.69*
Urinary Na+, meq/day	0.25 ± 0.03	0.39 ± 0.06*	0.22 ± 0.02	0.37 ± 0.03*
Body weight, g	20 ± 1	21 ± 1	20 ± 1	22 ± 1

Values are presented as means ± SE; n ≥ 5 for all groups. WT, wild type; PKC-α^−/−, PKC-α knockout.

^*P < 0.05 compared with untreated animals of the same genotype.