Figure 1.

Quantification of tumor-infiltrating immune cells. A total of 5000 CNS-1 cells were implanted in the striatum of Lewis rats, and 10 days later, rats received an intratumoral injection of Ad.Flt3L + Ad.TK followed by daily administration of GCV or, as controls, saline or an empty vector (Ad.0). At 5 and 12 days after the treatment, brain mononuclear cells were isolated from the brain tumors and analyzed using flow cytometry. Note that because control rats die of tumor burden at days 17 to 20, they cannot be included in day 22 analysis. *P < .05 versus saline. Kruskal-Wallis test followed by Dunn test.