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. Author manuscript; available in PMC: 2012 Aug 30.
Published in final edited form as: Cell. 2011 Oct 28;147(3):590–602. doi: 10.1016/j.cell.2011.09.034

Figure 1. Mapping of Interacting Domains.

Figure 1

(A) Domain representation of Nup58, Nup54, and Nup62 from Rattus norvegicus indicating α-helical (dark orange), α/β (brown), and unstructured regions (light orange) with FG repeats (black lines) (Melčák et al., 2007).

(B) Schematic representation of binding sites on Nup54 (blue) for Nup62 (gray) and Nup58 (pink). The α-helical and the unstructured regions with FG repeats are visualized as rods and coils, respectively.

(C) Coexpressed and purified Nup62-2·Nup54-2 (left) and Nup54-3·Nup58-2 (right) complexes were analyzed by SDS-PAGE and stained by Coomassie blue. See also Figure S1.