Table 1.
Baseline characteristics of patients included in study. Data are no (%) of patients unless stated otherwise
| Patients with cardiovascular disease | Patients without cardiovascular disease | Total | |
|---|---|---|---|
| No of patients (%) | 12 379 (9.8) | 113 713 (90.2) | 126 092 (100) |
| No of deaths (%) | 3535 (28.6) | 21 960 (19.3) | 25 495 (20.2) |
| Event rate per 1000 patient years | 82.9 | 45.3 | 48.3 |
| Age (years)* | 72.9 (10.7) | 66.4 (13.8) | 67.1 (13.7) |
| Male sex | 7178 (58.0) | 56 057 (49.3) | 63 235 (50.1) |
| Deprivation score† | 21.0 (22.7) | 20.6 (22.7) | 20.7 (22.7) |
| Smoking history | |||
| Current smoker | 1866 (15.1) | 17 659 (15.5) | 19 525 (15.5) |
| Ex-smoker | 4571 (36.9) | 32 393 (28.5) | 36 964 (29.3) |
| Non-smoker | 5515 (44.5) | 60 205 (52.9) | 65 720 (52.1) |
| Missing data | 427 (3.5) | 3456 (3.1) | 3883 (3.1) |
| Body mass index* | 28.2 (5.4) | 29.3 (6.1) | 29.1 (6.1) |
| Blood pressure at diagnosis (mm Hg)* | |||
| Systolic | 144.1 (21.3) | 146.4 (21.0) | 146.2 (21.1) |
| Diastolic | 80.3 (11.1) | 83.2 (11.0) | 82.9 (11.0) |
| Diagnosis of hypertension at baseline | 6597 (53.3) | 48 381 (42.55) | 54 978 (43.6) |
| Systolic blood pressure achieved during first year (mm Hg)* | 142.4 (19.2) | 144.3 (18.7) | 144.1 (18.7) |
| <130 mm Hg achieved (tight control) | 2773 (22.4) | 21 293 (18.7) | 24 066 (19.1) |
| 130-139 mm Hg achieved (usual control) | 2515 (20.3) | 22 562 (19.8) | 25 077 (19.9) |
| ≥140 mm Hg achieved (uncontrolled) | 7091 (57.3) | 69 858 (61.4) | 76 949 (61.0) |
| Diastolic blood pressure achieved during first year (mm Hg)* | 79.0 (9.6) | 81.8 (9.5) | 81.5 (9.5) |
| <80 mm Hg achieved (tight control) | 5841 (47.2) | 39 218 (34.5) | 45 059 (35.7) |
| 80-85 mm Hg achieved (usual control) | 3166 (25.6) | 31 714 (27.9) | 34 880 (27.7) |
| ≥85 mm Hg achieved (uncontrolled) | 3372 (27.2) | 42 781 (37.6) | 46 153 (36.6) |
| HbA1c at baseline (%)* | 7.2 (1.4) | 7.4 (1.6) | 7.4 (1.6) |
| Total cholesterol at baseline (mmol/L)* | 4.8 (1.1) | 5.2 (1.3) | 5.2 (1.4) |
| Anti-hypertensive drug use (at baseline) | |||
| Any | 9562 (77.2) | 57 741 (50.8) | 67 303 (53.4) |
| Monotherapy | 3796 (30.7) | 29 440 (25.9) | 33 236 (26.4) |
| Multiple therapy | 5766 (46.6) | 28 301 (24.9) | 34 067 (27.0) |
| Other drug use (at any time) | |||
| Lipid lowering | 5862 (47.3) | 46 638 (41.0) | 52 500 (41.6) |
| Oral antidiabetic | 5467 (44.2) | 58 893 (51.8) | 64 360 (51.0) |
| Insulin or oral antidiabetic | 5726 (46.3) | 61 264 (53.9) | 66 990 (53.1) |
| Aspirin or other antiplatelet | 9850 (79.6) | 52 366 (46.0) | 62 216 (49.3) |
*Mean (standard deviation).
†Median (interquartile range).