Table 1. MEF aneuploidy rates prior to reprogramming.
MEFgenotype | Line | Mitoticcellsinspected | Percentaneuploidcells | Karyotypes with the indicated chromosome number | |||||||||
35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | ||||
Wildtype | 1 | 50 | 12 | 1 | 1 | 1 | 1 | 44 | 2 | ||||
2 | 50 | 10 | 1 | 2 | 45 | 2 | |||||||
3 | 50 | 8 | 1 | 46 | 2 | 1 | |||||||
BubR1 H/H | 1 | 50 | 38 | 1 | 3 | 1 | 5 | 31 | 1 | 4 | 3 | 1 | |
2 | 50 | 40 | 3 | 2 | 3 | 3 | 30 | 3 | 4 | 1 | 1 | ||
3 | 50 | 36 | 4 | 3 | 1 | 2 | 32 | 4 | 2 | 2 | |||
RanBP2 –/H | 1 | 50 | 30 | 2 | 2 | 1 | 35 | 6 | 1 | 3 | |||
2 | 50 | 34 | 2 | 2 | 7 | 33 | 5 | 1 | |||||
3 | 50 | 34 | 2 | 1 | 2 | 5 | 33 | 2 | 3 | 2 |
Chromosome counts were performed at P5.