Table 2. Incidence of VGB-associated folding at the 1500 mg/kg dose.
VGB Dose (mg/kg) | Exposure (hours) | Light (lux) | Mouse | Total eyes | Negative | Positive | Frequency |
NO DRUG | 24 | 5000 | MF1 | 16 | 15 | 1 | 6% |
1500 | 24 | 5000 | MF1 | 20 | 13 | 7 | 35% |
1500 | 48 | 5000 | MF1 | 24 | 11 | 13 | 54% |