Table 1.
Characteristics of the selected IgAN patients (n=97) at time of diagnosis and last follow-up and according to the ARR of dialysis or death
| Characteristic | IgAN ARR = 0 | IgAN ARR = 1 | IgAN ARR = 2 | IgAN ARR = 3 | Statistics | IgAN All Patients |
|---|---|---|---|---|---|---|
| Patients (n) | 25 | 22 | 25 | 25 | 97 | |
| Men | 16 (64) | 16 (73) | 18 (72) | 23 (92) | NS | 73 (75) |
| At diagnosis | ||||||
| age (yr) | 37.8 (12.1) | 40.2 (12.4) | 45.7 (12.9) | 50.0 (16.1) | 43.6 (14.2) | |
| proteinuria (g/d) | 0.16 (0.22) | 0.90 (0.93) | 1.58 (1.04) | 3.56 (2.27) | 1.59 (1.87) | |
| class 0: <0.30 | 19 (76) | 6 (27) | 2 (8) | 0 (0) | 27 (28) | |
| class 1: 0.30–0.99 | 6 (24) | 8 (36) | 6 (24) | 0 (0) | χ2=79.03 | 20 (21) |
| class 2: 1.00–2.99 | 0 (0) | 7 (32) | 14 (56) | 11 (44) | P<0.0001 | 32 (33) |
| class 3: ≥3.00 | 0 (0) | 1 (4) | 3 (12) | 14 (56) | 18 (19) | |
| proteinuria ≥1 g/d | 0 (0) | 8 (36) | 16 (64) | 25 (100) | χ2=53.59 | 49 (50) |
| P<0.0001 | ||||||
| hypertension | 0 (0) | 10 (46) | 15 (60) | 25 (100) | χ2=51.54 | 50 (52) |
| P<0.0001 | ||||||
| GOS | 5.1 (1.2) | 6.0 (2.0) | 8.7 (1.9) | 13.3 (2.9) | 8.3 (3.8) | |
| GOS ≥8 U | 0 (0) | 4 (18) | 19 (76) | 25 (100) | χ2=65.67 | 48 (50) |
| P<0.0001 | ||||||
| eGFR (ml/min per 1.73 m2) | 82.0 (14.9) | 80.4 (22.3) | 64.2 (29.4) | 28.3 (25.7) | 63.2 (32.0) | |
| stage 1 | 7 (28) | 6 (27) | 6 (24) | 1 (4) | 20 (21) | |
| stage 2 | 17 (68) | 12 (54) | 9 (36) | 2 (8) | χ2=61.30 | 40 (41) |
| stage 3 | 1 (4) | 4 (18) | 5 (20) | 6 (24) | P<0.0001 | 16 (16) |
| stage 4 | 0 (0) | 0 (0) | 5 (20) | 5 (20) | 10 (10) | |
| stage 5 | 0 (0) | 0 (0) | 0 (0) | 11 (44) | 11 (11) | |
| At last follow-up: | ||||||
| exposure time (yr) | 13.8 (8.2) | 10.3 (6.1) | 15.4 (11.2) | 15.1 (12.1) | 13.8 (9.8) | |
| eGFR (ml/min per 1.73 m2) | 81.3 (17.7) | 72.9 (29.3) | 59.9 (35.6) | 16.9 (18.4) | 57.3 (36.1) | |
| stage 1 | 7 (28) | 8 (36) | 6 (24) | 0 (0) | 21 (22) | |
| stage 2 | 16 (64) | 9 (41) | 8 (32) | 1 (4) | 34 (35) | |
| stage 3 | 2 (8) | 3 (14) | 6 (24) | 4 (16) | χ2=58.33 | 15 (16) |
| stage 4 | 0 (0) | 0 (0) | 1 (4) | 3 (12) | P<0.0001 | 4 (4) |
| stage 5 | 0 (0) | 2 (9) | 4 (16) | 17 (68) | 23 (24) | |
| dialysis | 0 (0) | 2 (9) | 3 (12) | 16 (64) | χ2=36.76 | 21 (22) |
| P<0.0001 | ||||||
| death | 2 (8) | 0 (0) | 2 (8) | 1 (4) | NS | 5 (5.2) |
| D/D event | 2 (8) | 2 (9) | 5 (20) | 17 (68) | χ2=30.24 | 26 (27) |
| P<0.0001 |
Data are n (%) or mean (SD). D/D, outcome of dialysis/death; NS, not statistically significant.