. 2012 Sep;23(9):1579–1587. doi: 10.1681/ASN.2012010053

Table 2.

Serum levels of IgA, normalized and total autoantigen (Gd-IgA1), IgG, normalized and total IgG autoantibody, and normalized and total IgA autoantibody in controls (healthy, diseased, and combined) and in IgAN patients

	Healthy Controls	Diseased Controls	P Value(t and U Tests)	Combined Controls	All IgAN Patients	P Value (t and U Tests)
Patients (n)	30	30		60	97
IgA (mg/ml)	2.20 (0.76)	2.01 (0.81)	NS	2.10 (0.78)	2.88 (1.38)	0.0001
IgA (mg/ml)	2.09 (0.75–4.12)	1.98 (0.79–3.85)	NS	2.03 (0.75–4.12)	2.68 (0.49–8.01)	0.0003
Gd-IgA1 (% HAA)	31.3 (9.1)	36.1 (15.3)	NS	33.7 (12.7)	33.1 (12.4)	NS
Gd-IgA1 (% HAA)	29.5 (15.4–57.0)	31.3 (15.9–86.5)	NS	30.8 (15.4–86.5)	31.5 (10.0–76.5)	NS
Gd-IgA1 (U/ml)	68.2 (26.0)	71.5 (41.1)	NS	69.9 (34.1)	92.6 (49.4)	0.002
Gd-IgA1 (U/ml)	65.4 (16.7–112.3)	62.0 (25.3–184.3)	NS	63.4 (16.7–184.3)	84.4 (10.0–267.5)	0.003
IgG (mg/ml)	11.01 (2.64)	9.94 (4.05)	NS	10.47 (3.43)	10.32 (3.79)	NS
IgG (mg/ml)	10.54 (6.69–18.41)	9.81 (4.88–21.58)	NS	9.92 (4.88–21.58)	10.00 (1.33–25.77)	NS
IgG autoantibody (OD/0.5 µg)	1.172 (0.242)	1.300 (0.304)	NS (0.08)	1.236 (0.280)	1.483 (0.643)	0.006
IgG autoantibody (OD/0.5 µg)	1.195 (0.85–1.54)	1.272 (0.76–2.00)	NS	1.255 (0.76–2.00)	1.490 (0.63–3.01)	0.07 (NS)
IgG autoantibody (U/ml)	25.60 (7.28)	25.16 (10.58)	NS	25.38 (9.01)	30.79 (19.04)	0.04
IgG autoantibody (U/ml)	24.34 (14.88– 41.96)	24.55 (12.04–60.97)	NS	24.40 (12.04–60.97)	26.03 (5.72–91.62)	NS
IgA autoantibody (OD/1 µg)	0.549 (0.234)	0.770 (0.638)	NS (0.08)	0.660 (0.489)	0.748 (0.451)	NS
IgA autoantibody (OD/1 µg)	0.458 (0.29–1.13)	0.556 (0.24–2.84)	NS	0.493 (0.24–2.84)	0.589 (0.21–2.31)	NS (0.06)
IgA autoantibody (U/ml)	1.29 (0.91)	1.55 (1.37)	NS	1.42 (1.16)	2.33 (2.02)	0.002
IgA autoantibody (U/ml)	0.93 (0.28–3.45)	0.90 (0.19–5.99)	NS	0.91 (0.19–5.99)	1.78 (0.12–10.63)	0.002

Data are mean (SD) or median (range). NS, not statistically significant.