Table 3.
Serum levels of IgA, normalized and total autoantigen (Gd-IgA1), IgG, normalized and total IgG autoantibody, and normalized and total IgA autoantibody in subgroups of IgAN patients according to the ARR of dialysis/death
| Comparisons | IgAN ARR = 0 | IgAN ARR = 1 | IgAN ARR = 2 | IgAN ARR = 3 | |
|---|---|---|---|---|---|
| IgA (mg/ml) | Mean (SD) | 2.17 (0.99) | 2.87 (1.10) | 3.28 (1.52) | 3.21 (1.58) |
| Median (range) | 2.25 (0.49–4.23) | 2.85 (1.24–5.13) | 3.15 (1.36–7.62) | 2.95 (1.43–8.01) | |
| t test | Versus ARR = 0 | — | 0.02 | 0.003 | 0.01 |
| Versus all controls | NS | 0.001 | <0.0001 | <0.0001 | |
| Gd-IgA1 (% HAA) | Mean (SD) | 33.7 (13.5) | 32.6 (11.6) | 32.1 (14.6) | 34.2 (9.9) |
| Median (range) | 31.8 (17.1–73.1) | 32.0 (10.0–50.9) | 27.7 (13.4–76.5) | 32.0 (15.5–65.3) | |
| t test | Versus ARR = 0 | — | NS | NS | NS |
| Versus all controls | NS | NS | NS | NS | |
| Gd-IgA1 (U/ml) | Mean (SD) | 71.4 (37.5) | 90.8 (40.9) | 100.2 (54.6) | 107.8 (56.2) |
| Median (range) | 68.1 (10.0–155.3) | 93.7 (26.8–167.2) | 84.3 (24.3–211.0) | 87.0 (39.0–267.5) | |
| t test | Versus ARR = 0 | — | NS (0.10) | 0.03 | 0.01 |
| Versus all controls | NS | 0.02 | 0.003 | 0.0003 | |
| IgG (mg/ml) | Mean (SD) | 11.40 (2.69) | 10.94 (4.84) | 10.55 (3.79) | 8.47 (3.16) |
| Median (range) | 11.32 (5.62–16.08) | 9.75 (4.72–25.74) | 9.23 (6.71–21.72) | 8.65 (1.33–14.50) | |
| t test | Versus ARR = 0 | — | NS | NS | <0.001 |
| Versus all controls | NS | NS | NS | 0.01 | |
| IgG autoantibody (OD/0.5 µg) | Mean (SD) | 1.08 (0.36) | 1.23 (0.51) | 1.55 (0.71) | 2.05 (0.48) |
| Median (range) | 0.91 (0.63–1.73) | 0.95 (0.69–2.36) | 1.55 (0.68–3.01) | 2.13 (1.37–2.97) | |
| t test | Versus ARR = 0 | — | NS | 0.01 | <0.0001 |
| Versus all controls | 0.04 | NS | 0.01 | <0.0001 | |
| IgG autoantibody (U/ml) | Mean (SD) | 25.06 (11.45) | 28.38 (20.90) | 34.25 (23.33) | 35.18 (17.88) |
| Median (range) | 20.87 (9.73–48.26) | 23.28 (8.15–87.52) | 29.14 (10.15–91.72) | 30.84 (5.72–76.88) | |
| t test | Versus ARR = 0 | — | NS | NS (0.08) | 0.02 |
| Versus all controls | NS | NS | 0.01 | 0.001 | |
| IgA autoantibody (OD/1 µg) | Mean (SD) | 0.68 (0.50) | 0.69 (0.44) | 0.79 (0.47) | 0.83 (0.40) |
| Median (range) | 0.56 (0.23–2.19) | 0.56 (0.28–2,26) | 0.63 (0.21–2.31) | 0.69 (0.27–1.63) | |
| t test | Versus ARR = 0 | — | NS | NS | NS |
| Versus all controls | NS | NS | NS | NS | |
| IgA autoantibody (U/ml) | Mean (SD | 1.59 (1.37) | 2.19 (1.88) | 2.66 (2.02) | 2.88 (2.49) |
| Median (range) (OD/1µg) | 1.21 (0.12–1.37) | 1.77 (0.46–8.60) | 1.96 (0.29–9.50) | 2.14 (0.71–10.63) | |
| t test | Versus ARR = 0 | — | NS | 0.03 | 0.03 |
| Versus all controls | NS | 0.03 | 0.001 | 0.0004 |
NS, not statistically significant.