Figure 4.

CD47^−/− mice are protected against severe renal IRI. (A) Quantification of serum creatinine after bilateral renal ischemia and 24 hours reperfusion, in CD47^−/− mice (white bars), WT controls (black bars), and sham-operated mice (gray bars). Data are mean ±SD, n=8–10 per group. *P<0.001 CD47^−/− versus WT. (B) Representative renal tissue sections and quantitative analysis of tubular damage of corticomedulla from WT and CD47^−/− mice 24 hours after sham operation or ischemia-reperfusion (periodic acid–Schiff stained) are shown. Data shown are mean ± SD, n=8–10 per group, *P<0.001 CD47^−/− after IRI versus WT after IRI. Original magnification, ×200; inset, ×400 magnification insert.