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. 2012 Sep;22(9):1658–1667. doi: 10.1101/gr.136838.111

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© 2012, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 5. — Cell line specificity of the TF model. (A) Models trained and tested on data from the same cell line result in higher predictive accuracies. K Model and G Model represent models trained with data from K562 and GM12878, respectively. (B) Consistency of predicted log₂ fold changes with the experimentally measured differences between K562 and GM12878. Differential binding of 22 TFs are used as the predictors in a predictive model of differential expression. (C) The relative importance of TFs in K562- and GM12878-specific models as well as the predictive model for differential expression. (D) The power of each individual TF for classifying K562- and GM12878-specific promoters (log₂ fold change >2). CAGE expression data in Poly A+ RNA extracted from K562 and GM12878 whole cells were used in the calculation.