Table 1.

A List of Cellular IRES-Containing mRNAs, the Function of the Protein they Encode, and the ITAFs Identified to Date as Important for Their Activity

Cellular IRES-Containing mRNA	Encoded Protein Function	Identified ITAFs	References
Apaf-1	Pro-apoptotic	DAP5, hnRNPA1, PTB, UNR	[98]
Bag-1	Anti-apoptotic	PCBP1, PTB	[99]
Bcl-2	Anti-apoptotic	DAP5	[100]
BiP	ER protein chaperone	hnRNPQ, PTB	[31]
Cat-1	Amino acid transporter	hnRNPL, PTB	[101]
C-myc	Transcription factor	hnRNPA1, PCBP1, PCBP2, hnRNPK, GRSF1, NONO, PSF, PTB, YB1	[102, 103]
CDK1	Cell cycle control	DAP5	[104]
Cyclin D1	Cell cycle control	hnRNPA1	[105]
Cyclin T1	Cell cycle control	PTB	[32]
DAP5	Translation initiation	DAP5	[106]
FGF2	Growth factor	hnRNPA1	[107]
Hiap2	Anti-apoptotic	DAP5	[108]
HIF-1α	Transcription factor	PTB	[109]
IGFR	Growth factor receptor	PTB	[40]
Mnt	Transcription repressor	PTB	[110]
MTG8a	Transcription factor	PTB	[36]
p27 Kip1	Cell cycle control	PTB	[111]
p53	DNA damage response	PTB	[112, 113]
PDGF/c-sis	Growth factor	hnRNPC1/C2	[114]
PITSLRE	Cell cycle control	UNR	[115]
Rev-erbα	Transcription repressor	hnRNPQ, PTB	[116]
UNR	RNA stability, ITAF	hnRNPC1/C2, PTB, UNR	[117]
XIAP	Anti-apoptotic	hnRNPA1, hnRNPC1/C2, HuR, La, mdm2, PTB	[118]

Alternative names: PTB (hnRNPI), PCBP1 (hnRNPE1), PCBP2 (hnRNPE2). Abbreviations: heterogeneous nuclear ribonucleoprotein (hnRNP), PTB (polypyrimidine tract binding protein), UNR (upstream of N-ras), PCBP (poly (rC) binding protein), GRSF (G-rich RNA sequence binding factor), NONO (non-POU domain containing), PSF (splicing factor proline/glutamine rich), YB1 (Y-box binding protein).