. Author manuscript; available in PMC: 2012 Aug 31.

Published in final edited form as: Breast Cancer Res Treat. 2010 Nov 11;127(2):555–563. doi: 10.1007/s10549-010-1249-5

Table 4.

Results of linear regressions of mammographic density measures on inflammatory markers by control status^a

Benign controls
	Age-adjusted			Age- and BMI-adjusted			Fully adjusted^b
	N	β (SE)	P	N	β (SE)	P	N	β (SE)	P
Dense breast area
IL-6	145	−0.13 (0.28)	0.64	144	−0.07 (0.31)	0.83	111	−0.07 (0.39)	0.85
TNF-α	145	0.18 (0.37)	0.63	144	0.26 (0.39)	0.50	111	0.40 (0.50)	0.43
CRP	142	−0.01 (0.16)	0.95	141	0.001 (0.17)	0.99	109	0.16 (0.21)	0.45
Nondense breast area
IL-6	145	1.44 (0.39)	<0.001	144	0.23 (0.35)	0.52	111	0.09 (0.45)	0.84
TNF-α	145	1.46 (0.53)	0.007	144	0.50 (0.44)	0.26	111	0.03 (0.58)	0.96
CRP	142	0.70 (0.23)	0.003	141	0.16 (0.19)	0.42	109	0.06 (0.24)	0.82
Percent density
IL-6	145	−0.55 (0.23)	0.02	144	−0.08 (0.23)	0.74	111	−0.03 (0.30)	0.93
TNF-α	145	−0.42 (0.31)	0.18	144	−0.03 (0.29)	0.92	111	0.19 (0.35)	0.62
CRP	142	−0.26 (0.13)	0.06	141	−0.05 (0.13)	0.69	109	0.06 (0.17)	0.71

Well controls

	Age-adjusted			Age- and BMI-adjusted			Fully adjusted^†
	N	β (SE)	P	N	β (SE)	P	N	β (SE)	P

Dense breast area
IL-6	397	−0.16 (0.16)	0.32	397	−0.07 (0.17)	0.69	368	−0.15 (0.18)	0.41
TNF-α	394	−0.04 (0.23)	0.87	394	0.09 (0.24)	0.71	365	0.04 (0.25)	0.87
CRP	381	−0.06 (0.11)	0.57	381	0.01 (0.12)	0.96	353	0.02 (0.13)	0.85
Nondense breast area
IL-6	397	1.49 (0.24)	<0.001	397	0.39 (0.20)	0.05	368	0.34 (0.22)	0.12
TNF-α	394	1.78 (0.34)	<0.001	394	0.35 (0.28)	0.21	365	0.32 (0.30)	0.29
CRP	381	1.18 (0.16)	<0.001	381	0.27 (0.14)	0.06	353	0.29 (0.16)	0.06
Percent density
IL-6	397	−0.54 (0.14)	<0.001	397	−0.11 (0.14)	0.43	368	−0.13 (0.15)	0.38
TNF-α	394	−0.71 (0.20)	<0.001	394	−0.16 (0.19)	0.39	365	−0.17 (0.20)	0.41
CRP	381	−0.43 (0.09)	<0.001	381	−0.08 (0.10)	0.44	353	−0.07 (0.10)	0.48

Regressions performed using natural log transformations of the inflammatory markers and square root transformations of the mammographic measures

Adjusted for age, race, BMI, smoking, current NSAID use, first-degree relative with breast cancer, age at menarche, age at menopause, type of menopause, prior breast biopsy, ever been pregnant, and postmenopausal hormone therapy use.