Table 1.
Characteristics of cohort
T2D (n = 18) | Controls (n = 27) | P value | |
---|---|---|---|
Age (yr) | 58 ± 6 | 57 ± 5 | 0.38 |
Race | |||
Hispanic White | 12 | 10 | |
Caucasian | 4 | 13 | |
Hispanic Black | 2 | 1 | |
Asian | 0 | 2 | |
Native American | 0 | 1 | |
Duration postmenopausal (yr) | 12 ± 9 | 8 ± 4 | 0.05 |
Number of fractures | 5 (1 elbow, 1 ankle, 1 arm, 1 toe, 1 wrist) | 5 (1 5th digit, 2 foot, 1 wrist, 1 toe) | |
Height (in.) | 62 ± 2 | 63 ± 2 | 0.17 |
Weight (lb) | 175 ± 42 | 158 ± 32 | 0.13 |
BMI (kg/m2) | 32 ± 7 | 28 ± 6 | 0.06 |
Duration T2D (yr) | 9 ± 6 | ||
Number of diabetes medications used | |||
Metformin | 15 | ||
Glipizide | 5 | ||
Insulin | 2 | ||
Glimepiride | 1 | ||
Sitagliptin | 1 | ||
Serum calcium (mg/dl) | 9.4 ± 0.5 | 9.4 ± 0.3 | 0.75 |
Serum albumin (mg/dl) | 4.3 ± 0.2 | 4.4 ± 0.2 | 0.65 |
Serum creatinine (mg/dl) | 0.8 ± 0.2 | 0.8 ± 0.1 | 0.40 |
PTH (pg/ml) | 46 ± 26 | 40.9 ± 20 | 0.46 |
Total alkaline phosphatase (U/liter) | 97 ± 23 | 79 ± 29 | 0.03a |
25(OH)D (ng/ml) | 21 ± 11 | 29 ± 14 | 0.67 |
TSH (mIU/liter) | 2.9 ± 4 | 2.6 ± 3 | 0.80 |
Glucose (mg/dl) | 169 ± 94 | 107 ± 8 | <0.001a |
HbA1c (%) | 8.4 ± 2b | 5.8 ± 0.3 | <0.001a |
Lumbar spine | |||
g/cm2 | 0.967 ± 0.16 | 0.920 ± 0.10 | 0.24 |
T score | −0.56 ± 1.5 | −1.1 ± 1.0 | 0.28 |
Femoral neck | |||
g/cm2 | 0.778 ± 0.15 | 0.708 ± 0.09 | 0.06 |
T score | −0.8 ± 1.2 | −1.3 ± 0.7 | 0.08 |
Total hip | |||
g/cm2 | 0.935 ± 0.18 | 0.835 ± 0.11 | 0.03a,c |
T score | −0.2 ± 1.3 | −0.9 ± 0.8 | 0.04a,c |
1/3 distal radius | |||
g/cm2 | 0.672 ± 0.07 | 0.654 ± 0.06 | 0.35 |
T score | −0.5 ± 1.2 | −0.7 ± 1.0 | 0.61 |
To convert calcium to millimoles per liter, multiply by 0.25; albumin to grams per liter, multiply by 10; creatinine to micromoles per liter, multiply by 88.4; PTH to nanograms per liter, multiply by 1; 25(OH)D to nanomoles per liter, multiply by 2.496; glucose to millimoles per liter, multiply by 0.056.
P < 0.05.
Six T2D had HbA1c higher than 7.9%.
No longer significant after adjusting for BMI.