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Genes with GWAS-identified genetic loci associated with insulin secretion and resistance and conferring a 15–20% increased risk of type 2 diabetes
| Genes | |
|---|---|
| Genes associated with reduced insulin secretion | |
| Reduced β-cell mass | CDKAL1, CDKN2A, CDKN2B |
| β-cell dysfunction | MTNR1B, TCF7L2, KCNJ11 |
| Genes associated with insulin resistance | |
| Obesity | FTO |
| Insulin resistance unrelated to obesity | IRS1, PPARG |
