Table 5.
Novel GWAS-identified loci associated with type 2 diabetes in non-European populations
| Population | Newly identified SNP | Chromosome | Associated gene(s) | Associated physiological function |
|---|---|---|---|---|
| South Asians (45) | rs3923113 | 2 | GRB14 | Associated with insulin sensitivity |
| rs16861329 | 3 | ST6GAL1 | Associated with pancreatic β-cell function | |
| rs1802295 | 10 | VPS26A | ||
| rs7178572 | 15 | HMC20A | ||
| rs2028299 | 15 | AP3S2 | ||
| rs4812829 | 20 | HNF4A | Associated with pancreatic β-cell function | |
| East Asians (46) | ||||
| Loci with strong associations | rs6815464 | 4 | MAEA | |
| rs7041847 | 9 | GLIS3 | Associated with pancreatic β-cell development, insulin gene expression, and glucose | |
| rs6017317 | 20 | FITM2-R3HDML-HNF4A | ||
| rs6467136 | 7 | GCC1-PAX4 | ||
| rs831581 | 3 | PSMD6 | ||
| rs9470794 | 6 | ZFAND3 | ||
| rs3786897 | 19 | PEPD | ||
| rs1535500 | 6 | KCNK16 | May regulate glucose-independent insulin secretion in the pancreas | |
| Loci with moderate associations | rs16955379 | 16 | CMIP | |
| rs17797882 | 16 | WWOX | ||
| NHBs (47) | ||||
| Loci with strong associations | Rs7560163 | 2 | RBM43, RND3 | |
| Loci with nominal associations | Rs7542900 | 1 | SLC44A3, F3 | |
| Rs4659485 | 2 | RYR2, MTR | ||
| Rs2722769 | 11 | GALNTL4, LOC729013 | ||
| Rs7107217 | 11 | TMEM45B, BARX2 |