Fig. 2.
Benzamil reduces Cl− absorption in the CCD of Aldo-treated mice. JCl (left) and VT (right) were measured simultaneously in CCDs from Aldo-treated mice (treatment 1) in either the presence or absence of 3 μM benzamil in the luminal fluid. ANG II (10−8 M) was present in the bath. Solid lines indicate results from experiments where the vehicle was applied in the first period and benzamil was applied in the second period. Dashed lines indicate experiments where the order was reversed (i.e., benzamil was applied in the initial period and then removed in the second period). Open squares show means ± SE under each condition.