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Possible role of NKCC1 in Cl− transport in the mouse CCD. The transporters present in the CCD are shown (4, 11, 14, 46). In the CCD of Aldo-treated mice, Cl− secretion may be through NKCC1-mediated Cl− uptake across the basolateral membrane of type A intercalated cells in tandem with an apical Cl− conductive pathway. This apical conductive pathway should be stimulated when the lumen-negative voltage is abolished with amiloride analogs, such as benzamil.
