Table 1.

Cellular actions of pro-resolving mediators

Pro-resolving mediator	Cell type	Action	Reference
Lipoxin A4	Eosinophils	Inhibits of eosinophil migration	10
	T cells	Inhibits of TNF release	4
	Neutrophils	Inhibits PMN chemotaxis	102
		Inhibits trans-endothelial migration	34,76
		Inhibits trans-epithelial migration	34
		Inhibits of superoxide anion generation	64
		Inhibits of azurophilic granule release	108
	NK cells	Inhibits NK cell cytotoxicity	80
	Monocytes	Increases adhesion and transmigration	67
		Inhibits IL-8 released induce by TNF	20
	Macrophages	Increases engulfment of apoptotic PMN	46
	Smooth muscle	Inhibits LTC4-initiated migration	77
	Endothelium	Stimulates prostacyclin release	22
	Epithelial cells	Increases proliferation after acid injury	18
		Inhibits cytokine release	18
		Increases intracellular Ca2+	19
Resolvin E1	T cells	Increases CCR5 expression	5
	Neutrophils	Inhibits of trans-endothelial migration	25
Protectin D1	T cells	Increases CCR5 expression	5
	Neutrophils	Inhibits TNFα and IFNγ release	6
		Inhibits PMN trans-migration	12