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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Clin Chest Med. 2012 Jul 25;33(3):559–570. doi: 10.1016/j.ccm.2012.06.006

Table 2.

Uncontrolled asthma – A defect in pro-resolving mediators

Pro-resolving
mediator		 Evidence Age Country Reference
Lipoxin A4 Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Adults Poland 84
Diminished lipoxin biosynthesis in severe asthma Adults USA 61
Severe asthma is associated with a loss of LXA4, an endogenous anti-inflammatory compound. Adults France 112
Lipoxin A4 levels in asthma: relation with disease severity and aspirin sensitivity Adults Turkey 28
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Adults USA 78
The role of lipoxin A4 in exercise-induced bronchoconstriction in asthma Adults Turkey 111
Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Adults UK 15
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. Children China 118
Protectin D1 Generated in asthma and dampens airway inflammation and hyper-responsiveness. Adults US 65