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. Author manuscript; available in PMC: 2012 Aug 31.
Published in final edited form as: Clin Exp Metastasis. 2008 Aug 20;25(7):835–841. doi: 10.1007/s10585-008-9199-6

Fig. 1.

Fig. 1

Sinusoidal vascular architecture and cancer cell intravasation in primary liver tumor. (a) Basic structure of HCC forming thick trabecular pattern (hematoxylin-eosin stain, original magnification 100×). Immunostaining of CD31 (b) and laminin (c) shows sinusoidal tumor vasculature with basement membrane surrounding the tumor nests (original magnification, panel b, 100×; panel c, 400×). (d, e) Intravasation of HCC. (d) Multiple tumor nests move into an efferent vein (EV) from the primary tumor (PT) without destruction of the vascular wall (hematoxylin-eosin stain, original magnification 100×). (e) The tumor emboli conserve their trabecular architecture with endothelial coverage during the intravasation process (immunostaining of CD31, original magnification 100×)