Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic model for the prionoid conversion and negative dominance of mutant p53. The native conformations of WT and R248Q p53 are represented as green and orange molecules, respectively. The misfolded conformation of either molecule is represented in purple. According to the model, the prion-like character responsible for the negative dominance effect would occur in the oligomers.
