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A, superposition of AL-09 2YF (orange) crystal structure onto one monomer of AL-09 (green); significant structural alterations in the left side monomers are the result of the altered dimer interface of AL-09 B, (red box). Shown is a detailed view of the Tyr-to-Phe mutations (from residues 30–36 and 91–97)). C (blue box), close up of alterations in loop of one monomer between β-strands C and C′ (residues 39–44).
