TABLE 2.

Mutability index for WT and AID mutants

The mutability index is defined as the number of times a given trinucleotide motif within a segment of DNA contains a mutation, divided by the number of times the oligonucleotide would be expected to be mutated for a mechanism with no sequence bias (5, 40).

Motif	Mutability index
	WT	F15L	S43P	L98R	R174S	ΔC15	ΔC10
Hot spots
AAC	1.75	1.65	1.87	1.72	1.84	1.65	2.21
AGC	1.61	1.55	1.97	1.48	1.74	1.59	2.15
TAC	2.05	2.10	1.84	2.38	2.26	2.20	2.13
TGC	1.97	1.93	2.01	2.16	1.90	2.06	2.96
MI average (WRC)	1.85	1.81	1.92	1.94	1.94	1.88	2.36
Cold spots
CCC	0.50	0.59	0.40	0.59	0.56	0.42	0.32
CTC	0.68	0.53	0.46	0.54	0.48	0.53	0.33
GCC	0.32	0.15	0.13	0.17	0.27	0.13	0.02
GTC	0.53	0.31	0.46	0.29	0.45	0.30	0.46
MI average (SYC)	0.51	0.40	0.36	0.40	0.44	0.35	0.28
Intermediates
ACC	0.88	0.94	0.62	0.82	0.94	0.91	0.56
ATC	1.10	1.44	0.86	1.61	2.11	0.98	0.59
CAC	0.99	1.08	0.91	0.92	1.01	1.09	0.81
CGC	1.09	1.00	1.52	1.01	1.03	1.25	1.47
GAC	0.43	0.44	0.58	0.44	0.19	0.65	0.59
GGC	0.72	0.76	0.77	0.77	0.56	0.81	0.42
TCC	1.03	1.02	0.89	0.99	0.63	0.84	0.64
TTC	0.76	0.98	0.71	0.93	0.82	0.83	0.62
MI average	0.88	0.96	0.86	0.94	0.91	0.92	0.71