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. 2012 Aug 8;13(8):9900–9922. doi: 10.3390/ijms13089900

Figure 1.

Figure 1

Epialleles in the ddm1 mutant. (a) In WT (wild type) plants, expression of the FWA gene is repressed by DNA methylation of a promoter region-harboring short interspersed nuclear element (SINE) (left). In ddm1 mutants, decreased DNA methylation in the SINE element induces ectopic expression of the FWA gene (right); (b) BONSAI (BNS) gene is flanked by LINE sequences, which are hyper-methylated, in tail-to-tail manner. In ddm1 mutants, DNA methylation spreads into the BNS gene from the LINE sequence in a CMT3-KYP dependent manner, and stochastically induces silencing of the BNS gene.