Table 1.
Clinicopathological characteristics of patients according to phosphatase and tensin homolog (PTEN) expression pattern.
| Characteristic | Total Number | Cytoplasmic PTEN Negative | p Value | Nuclear PTEN Negative | p Value | Total PTEN Negative | p Value | Ca/CN Total ≤ 0.5 | p Value |
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||||
| 15 (29%) | 43 (84%) | 13 (25%) | 29 (57%) | ||||||
| Sex | |||||||||
| M | 45 | 13 (29%) | 1 | 38 (84%) | 1 | 11 (24%) | 0.638 | 26 (58%) | 1 |
| F | 6 | 2 (33%) | 5 (83%) | 2 (33%) | 3 (50%) | ||||
| Age | |||||||||
| Median | 52 | 55 | 52 | 54 | |||||
| Range | 43–72 | 38–72 | 43–72 | 39–72 | |||||
| Histological grade | |||||||||
| I | 4 | 1 (25%) | 0.478 | 4 (100%) | 0.404 | 1 (25%) | 0.106 | 1 (25%) | 0.043 a |
| II | 34 | 9 (26%) | 29 (85%) | 7 (21%) | 17 (50%) | ||||
| III | 11 | 5 (45%) | 8 (73%) | 5 (45%) | 9 (82%) | ||||
| TNM stage | |||||||||
| I | 38 | 13 (34%) | 0.336 | 33 (87%) | 0.564 | 11 (29%) | 0.419 | 22 (58%) | 0.406 |
| II | 5 | 0 (0%) | 4 (80%) | 0 (0%) | 3 (60%) | ||||
| III | 6 | 2 (33%) | 4 (67%) | 2 (33%) | 4 (67%) | ||||
| IV | 2 | 0 (0%) | 2 (100%) | 0 (0%) | 0 (0%) | ||||
| Depth of invasion | |||||||||
| T1 | 40 | 13 (33%) | 0.315 | 35 (88%) | 0.409 | 11 (28%) | 0.37 | 22 (55%) | 0.856 |
| T2 | 5 | 0 (0%) | 4 (80%) | 0 (0%) | 3 (60%) | ||||
| T3 | 6 | 2 (33%) | 4 (67%) | 2 (33%) | 4 (67%) | ||||
| Lymph node metastasis | |||||||||
| N0 | 50 | 15 (30%) | 0.515 | 42 (84%) | 0.663 | 13 (26%) | 0.555 | 29 (58%) | 0.246 |
| N1 | 1 | 0 (0%) | 1 (100%) | 0 (0%) | 0 (0%) | ||||
| Distant metastasis | |||||||||
| M0 | 50 | 15 (30%) | 0.515 | 42 (84%) | 0.663 | 13 (26%) | 0.555 | 29 (58%) | 0.246 |
| M1 | 1 | 0 (0%) | 1 (100%) | 0 (0%) | 0 (0%) |
a
Histological grades I–II versus grade III;
Ca, carcinoma tissue; CN, adjacent non-neoplastic tissue.