Table 1.
Studies reporting a tumor suppressor role for βig-H3.
| Cell Type | Observation | References |
|---|---|---|
| CHO cells | βig-H3 inhibits cell attachment in vitro and suppresses the growth of CHO tumor cells in nude mice | [48] |
| RGD peptides released from βig-H3 mediate apoptosis of CHO tumor cells | [49] | |
| HeLa cells | RGD peptides released from βig-H3 mediate apoptosis of HeLa tumor cells | [49] |
| Bronchial epithelial cells | βig-H3 overexpression suppresses tumorigenicity in radiation-induced tumorigenic human bronchial epithelial cells | [50] |
| Loss of βig-H3 expression is associated with the tumorigenic phenotype in asbestos-treated bronchial epithelial cells | [51] | |
| βig-H3 gene down-regulation is involved in heavy-ion radiation-induced tumorigenesis of human bronchial epithelial cells | [52] | |
| Lung adenocarcinoma | Loss of βig-H3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells | [53] |
| Promoter methylation contributes to promoter silencing of the βig-H3 gene in human lung cancer cells | [47] | |
| βig-H3 is down-regulated in radiation-induced thymic lymphoma model in BALB/c mice | [5] | |
| βig-H3 overexpression in H522 lung carcinoma cells reduces motility in vitro and metastasis in vivo | [54] | |
| RGD βig-H3 peptides mediate apoptosis of H1299 lung carcinoma cells | [49] | |
| Mesothelioma cell lines | βig-H3 knockdown increases proliferation and anchorage independent growth of mesothelioma cell lines | [55] |
| Breast carcinoma | βig-H3 protein expression is reduced in in situ ductal carcinoma and breast carcinoma tissues, compared to benign tissues | [54] |
| βig-H3 overexpression in MCF-7 cells reduces motility in vitro and metastasis in vivo | [54] | |
| Neuroblastoma | βig-H3 significantly reduces proliferation and invasion of neuroblastoma cell in vitro and in vivo | [2,56] |
| Osteosarcoma | C-terminal fragment of βig-H3 is required for apoptosis in human osteosarcoma cells | [57] |
| Hepatoma | RGD βig-H3 peptides mediate apoptosis of Hep3B hepatoma cells | [47] |
| Knockout mice | βig-H3 knockout mice are prone to spontaneous tumors | [58] |
| Ovarian carcinoma | βig-H3 silencing and promoter hypermethylation is a frequent occurrence in ovarian cancer cell lines and ovarian cancer tissues | [59,60] |
| βig-H3 is down-regulated in serous ovarian carcinoma and borderline serous ovarian tumors | [61] | |
| βig-H3 induces apotosis in serous ovarian carcinoma cell lines | [61] |