Table 2.
Studies reporting a tumor-promoting role for βig-H3.
| Cell type | Observation | References |
|---|---|---|
| Lung adenocarcinoma | βig-H3 is overexpressed in lung cancer | [6] |
| Recombinant βig-H3 stimulates proliferation and cell adhesion of A549 cells | [20] | |
| Oesophageal adenocarcinoma | βig-H3 is up-regulated in oesophageal adenocarcinoma and esophageal squamous cell carcinoma tissues and cell lines tissue | [65,78,79] |
| Pancreatic cancer | βig-H3 expression is increased in pancreatic cancer cell lines and tissues | [68,80] |
| Oral squamous cell carcinoma | βig-H3 expression is increased in oral squamous cell carcinoma tissues | [81] |
| Brain tumors | βig-H3 promotes cell adhesion of human astrocytoma cells in vitro via interactions with α6β4 integrin | [72] |
| βig-H3 expression is elevated in glioblastoma multiforme tissues | [82] | |
| Knockdown of βig-H3 inhibits glioma cell invasion and MMP secretion | [83] | |
| Hepatocellular carcinoma | βig-H3 knockdown reduced invasion of 7721 cells | [73] |
| βig-H3 interacts with α3β1 integrin to promote adhesion and invasion of 7721 cells | [74] | |
| Colon carcinoma | βig-H3 expression is elevated in human colon carcinoma tissues | [64,84] |
| Overexpression of βig-H3 promotes extravasation and enhances metastasis of colon cancer cells | [71] | |
| Renal cell carcinoma | βig-H3 is up-regulated in clear cell renal carcinoma | [63,64] |
| βig-H3 expression is increased in metastastic renal cell carcinoma | [85] | |
| Ovarian carcinoma | βig-H3 suppression leads to a chemoresistant phenotype | [86,87] |
| Recombinant βig-H3 promotes motility and invasion of OVCAR-5 and SKOV3 cells | [61] | |
| Recombinant βig-H3 promotes adhesion of OVCAR-3, OVCAR-5 and SKOV3 cells | [61] |