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. 2012 Aug 22;13(8):10568–10582. doi: 10.3390/ijms130810568

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Schematic of CA125. (A) A diagrammatic overview of the molecular structure of CA125 as described by O’Brien et al. [18,21]; (B) A typical repeat unit of 156 amino acids and the possible features assigned to this sequence. At least 60 repeats have been identified, of which 45 are unique sequences, giving rise to a minimum domain length of 9800 aa [18]. Serine/Threonine rich region downstream of SEA domain was unspecified [18], O-glycosylation potential of a randomly chosen repeat unit (aa 14,255–14,410) was determined by submission to NetOGlyc 3.1 Server [25] (aa 131–156); (C) Carboxy terminal domain: aa 21,869–22,152 (length: 284 aa) [18] (aa numbering according to UniProt [26]).

Schematic of CA125. (A) A diagrammatic overview of the molecular structure of CA125 as described by O’Brien et al. [18,21]; (B) A typical repeat unit of 156 amino acids and the possible features assigned to this sequence. At least 60 repeats have been identified, of which 45 are unique sequences, giving rise to a minimum domain length of 9800 aa [18]. Serine/Threonine rich region downstream of SEA domain was unspecified [18], O-glycosylation potential of a randomly chosen repeat unit (aa 14,255–14,410) was determined by submission to NetOGlyc 3.1 Server [25] (aa 131–156); (C) Carboxy terminal domain: aa 21,869–22,152 (length: 284 aa) [18] (aa numbering according to UniProt [26]).