Table 1.
Features described from the CA125 amino acid sequence based on the data of O’Brien [18,21], Yin [17], Maeda [22] and Berman [23]; Amino acid (aa) number (numbering derived from [18]) indicates the position of those residues as they appear within the respective domain. bp: base pairs.
| Domain | Carboxy Domain | Repeat Domain | Amino Domain |
|---|---|---|---|
| Features | |||
| Exons | 9 | 5 | 9 |
| Nucleotides (bp) | 14,000 | Single: 1900 Cumulative: Unknown |
50,950 |
| Amino Acids (aa) | 284 | Single: 156 Cumulative: >9360 |
12,068 |
| Molecular Characteristics | Stop CodonPoly A Signal Potential Transmembrane Region (aa 230–252) Potential Cytoplasmic Region (aa 256–260) Potential Proteolytic Cleavage Sites (aa 171–181 [18] and aa 35/36 [22]) |
SEA domain Cysteine loop (aa 59,79) [23] Conserved Methionine (aa 24) Serine/Threonine/Proline Rich |
Serine/Threonine Rich(Abundant O-glycosylation Potential, N-glycosylation Potential) |