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. 2012 Aug 1;32(31):10574–10586. doi: 10.1523/JNEUROSCI.0893-12.2012

Figure 3.

Figure 3.

The C57BL/6 background protects against TTA-induced dentate granule cell loss. a, The hippocampus of congenic B6 CaMKIIα-TTA mice appeared identical to NTG at all ages tested. b, The width of the dentate granule cell layer was used to estimate the extent of degeneration in hybrid TTA transgenic mice and in mice backcrossed to B6. On the B6/CBA/C3 hybrid background, the width of the dentate granule cell layer was significantly thinner in TTA-expressing animals than in NTG siblings at both 2–4 months and 6–9 months of age. Moreover, the width decreased with age and was significantly thinner in TTA transgenic mice at 6–9 months than it was at 2–4 months. In contrast, the width of the granule cell layer in congenic B6 TTA mice (backcross generation N19–N24) was no different from NTG at either age tested. n = 5–7 mice per genotype for each age group. Open circle, NTG; filled circles, TTA. *p < 0.05, ***p < 0.001, two-way ANOVA with Bonferroni post hoc test. Scale bar, 300 μm.