Figure 7.

Strain-dependent effects of TTA expression on contextual fear conditioning. a, Freezing responses during the 5 min context test varied significantly with strain, but the average percentage time spent freezing did not differ between genotypes on any background tested. b, Minute-by-minute freezing for the four strain backgrounds (NTG: dotted lines, open circles; TTA: solid lines, filled circles). On the B6129 background, there was a noticeable divergence between the two genotypes over time. Similarly, freezing responses in B6DBA TTA and NTG mice diverged significantly over time during testing. In contrast, there was no difference in freezing between genotypes on the B6FVB or congenic C57BL/6 background over time (n = 10–14 per genotype). Two-way RM ANOVA with Bonferroni post hoc test, *p < 0.05.