Table 1.
Characteristics of T Cells Responding to Different Types of Viral Infections
| Type of Infection Phenotype of T Cells Functional Properties | Examples of Infections | |
|---|---|---|
| Acute viral Infection (Memory Phase) | ||
| CD62LHi > CD62LLo | –High proliferative potential | LCMV (Acute Strains) |
| CD44Hi | –Potent effector functions (IFN-γ, TNF-α, IL-2, cytotoxicity) | VSV |
| CD27Int/Hi | –Potent homeostatic turnover | Vaccinia virus |
| CD11aHi | –Antigen-independent persistence | Influenza virus |
| CCR7Hi | RSV | |
| CD127Hi | Sendai Virus | |
| CXCR3Hi | ||
| KLRG1Lo | ||
| CD122Hi | ||
| CD43Lo | ||
| PD-1Lo | ||
| CD69Lo | ||
| CD57Lo | ||
| Latent, Reactivating Infection | ||
| CD62LLo > CD62LHi | –Intermediate proliferative potential | γHV |
| CD44Hi | –Weaker effector functions (lower IFN-γ, TNF-α, IL-2) | EBV |
| CD27Lo/Int | –Reduced homeostatic turnover | CMV |
| CD11aHi | HSV | |
| CCR7Lo/Hi | ||
| CD127Lo/Int | ||
| CD122Lo | ||
| KLRG1Hi/Lo | ||
| PD-1Int/Hi | ||
| CD69Lo | ||
| CD57Hi | ||
| Chronic, Persistent Infection | ||
| CD62LLo | –Low proliferative potential | LCMV (chronic strains) |
| CD27Lo/Int | –Poor effector functions (exhausted) | HCV |
| CD44Hi | –Little or no homeostatic turnover | HIV |
| CCR7Lo | –Antigen-dependent persistence | SIV |
| CD11aHi | ||
| CD122Hi/Lo | ||
| CD127Lo/int | ||
| PD-1Hi | ||
| KLRG1Hi/Lo | ||
| CD57Hi | ||
| CD69Hi | ||