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. Author manuscript; available in PMC: 2012 Aug 31.
Published in final edited form as: Immunity. 2011 Nov 23;35(5):792–805. doi: 10.1016/j.immuni.2011.09.017

Figure 2. STAT3 acts in a CD8+ T cell autonomous manner to generate a long-lived pool of mature memory CD8+ T cells.

Figure 2

(A) Mice that received a small number (5×105) of P14 TCR-tg Stat3+/+ (filled square) and Stat3−/− (open circle) cells were infected with LCMV. P14 CD8+ T cells in spleen were enumerated at day 8, 40 and 80 p.i. Numbers of total P14, KLRG1lo IL-7Rhi and KLRG1hi IL-7Rlo subsets were plotted in line graphs. (B) Dot plots show the expression of KLRG1 and IL-7R in P14 CD8+ T cells at day 8 and 80 p.i. (C) Histograms show the expression of CD27, CD122, Granzyme B and BCL-2, and percentage of CD62L+ and IL-2+ in P14 Stat3+/+ (shaded histogram) and Stat3−/− (dashed line histogram) CD8+ T cells at day 80 p.i. MFI or percentage of “positive” cells shown in the upper left corner.