Figure 4. Both IL-10 and IL-21 promote memory CD8⁺ T cell differentiation.

(A) WT and Il21−/− mice were infected with LCMV and either treated with αIL-10 mAb or mock injected with PBS for 25 days. (A) KLRG1 and IL-7R expression on D^bGP_33–41 tetramer⁺ CD8⁺ T cells was examined at days 25 p.i. (B) The numbers of total D^bGP_33–41 tetramer⁺ (open bars) and KLRG1^lo IL-7R^hi (black bars) CD8⁺ T cells at day 25 p.i. are shown in the stacked bar graphs. Data shown are representative of two independent experiments (Statistical analyses show the comparison between KLRG1^lo IL-7R^hi groups, * denotes p<0.05 and n.s. denotes “not significant”).