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. 2012 Sep 1;23(17):3357–3369. doi: 10.1091/mbc.E12-03-0213

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© 2012 Virtakoivu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — AKT kinases regulate prostate cancer cell invasion. (A) Invasion of AKT-silenced PC3 cells in Matrigel. siRNA-transfected cells were allowed to invade for 4 d and were then stained with Alexa Fluor 488 phalloidin. Cells were imaged with confocal microscopy. Side view (z-axis) of invading cells and x-y views of cells from the bottom (20 μm) and close to the top (invaded distance: 70 μm) of the Matrigel plug. Arrow indicates invasion direction. Analysis of invasion area was done with ImageJ (mean ± SEM; *, p < 0.05, **, p < 0.005; eight invasion areas were analyzed per experiment; n = 2). (B) Invasion of AKT-silenced and Mab13-treated PC3 cells (mean ± SEM; **, p < 0.005, ***, p < 0.0005; eight invasion areas were analyzed per experiment; n = 2).