FIGURE 1:

Self-interaction of Cx26TM1 at the bacterial plasma membrane is affected by mutation or deletion of amino acids 37–40. The graph depicts the growth of bacteria (absorbance at 600 nm) transformed with constructs containing the wild-type Cx26TM1 (TM1), deafness-related variants (V37I and A40G), the truncated form (DelVVAA), Cx43-like Cx26TM1chimera (GTAV), or the pML27 plasmid alone that were subjected to TOXCAT analysis after incubation at increasing concentrations of chloramphenicol (20–120 μg/ml) for 10 h.