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. 2012 May 10;9:E95. doi: 10.5888/pcd9.110301

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The left side of this figure shows that classical inflammation is ultimately resolved after inflammation, an immune defense reaction, and resolution. Metaflammation results in a low-level dysmetabolism, which can ultimately result in chronic disease. The order and other possible actions associated with metaflammation on the right side of the figure (ie, oxidative stress, metaflammation, and insulin resistance) are suggestive only but imply the mix of dysmetabolic actions associated with metaflammation. Adapted from Egger and Dixon (10). Abbreviation: LDL, low-density lipoprotein. — A representation of the difference between classical inflammation (illustrated as raging fire), initiated by a microbial antigen or injury, and metaflammation (illustrated as smoldering fire), caused by inorganic “anthropogens.” Adapted from Egger and Dixon (10). Abbreviation: LDL, low-density lipoprotein. The scale of difference of immune reaction between the 2 forms (ie, approximately 100-fold) is not shown.