|
Treatment can commence immediately in the presence of at least one of the following organ/system failures combined with sepsis: |
|
Respiratory:
|
| PaO2/FiO2 <300 |
|
Cardiovascular (at least one of the following criteria in the absence of hypovolemia): |
| SAP <90 mmHg or decrease >40 mmHg with signs of peripheral hypoperfusion |
| Use of inotropic or vasopressor drugs to maintain SAP >90 mmHg |
|
Renal (at least one of the following criteria in the absence of chronic renal failure): |
| Creatinine levels >300 µmol/l |
| Diuresis <500 ml/24 h or 180 ml/8 h |
| Patients requiring dialysis |
|
Central Nervous (at least one of the following criteria): |
| Glasgow score <6 (in absence of sedation) |
| Sudden onset of confusional syndrome |
|
Hepatic (at least one of the following criteria): |
| Bilirubin >100 µmol/l |
| Alkaline phosphatase >×3 normal level |
|
Coagulation (at least one of the following criteria): |
| Hematocrit 20% |
| Leukocytosis <2000/mm3
|
| Platelets <40 000/mm3
|
