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. 2012 Aug 31;7(8):e43429. doi: 10.1371/journal.pone.0043429

Figure 2. Rv2190c expression peaks at log phase and is involved in the response to cell wall disruption.

Figure 2

A. Fold change of Rv2190c expression (relative to level at the start of the growth curve) over increasing cell density in 7H9 broth in wild-type M. tuberculosis CDC1551, normalized to sigA expression. pc: post-clumping. B. Fold-change of Rv2190c expression after exposure to oxidative (cumene), disulfide (diamide) and detergent (SDS) stress conditions, relative to expression levels prior to addition of stressors and normalized to sigA. C. Survival of WT, the Rv2190c mutant and complement M. tuberculosis strains following 24 hours of lysozyme exposure. D. PDIMs for M. tuberculosis WT and Rv2190c mutant strains analyzed by thin layer chromatography using hexane∶diethyl ether∶acetic acid solvent. E. PDIMs analyzed using petroleum ether∶diethyl ether solvent.