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(A) The structure of the stapled BH3 peptide (BH3D) taken from its complex with MCL-1 as crystallized in the x-ray structure (3MK8) is shown in cartoon. The staple linking amino acid positions i and i+4 is shown in sticks and the C-α atoms are shown in spheres for clarity, (B) The chemical structure of the i, i+4 staple used.
