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. 2012 Aug 31;7(8):e43985. doi: 10.1371/journal.pone.0043985

Table 2. Binding free energy (in kcal/mol) of MCL-1 with wt and stapled BH3peptides.

Δ(binding) BH3wt BH3A BH3B BH3C BH3D BH3E BH3F BH3G BH3H BH3I BH3J BH3K
ΔH −67.4(5.3) −66.8(6.2) −62.5(8.3) −52.9(5.2) −63.2(4.7) −68.1(4.6) −64.6(4.9) −68.2(5.4) −68.7(4.7) −71.7(5.9) −70.3(4.5) −72.7(4.7)
−TΔS 40.1(5.6) 38.8(5.4) 36.9(5.3) 41.6(6.3) 36.9(4.6) 41.3(4.4) 38.4(5.4) 41.7(4.2) 35.4(5.1) 38.3(5.6) 38.5(4.5) 39.0(5.3)
ΔGbind −27.3 −27.9 −25.6 −11.2 −26.3 −26.8 −26.1 −26.4 −33.4 −33.5 −31.7 −33.7