Figure 4. Phenotypic profiling of bone marrow and spleen cells indicates dissemination of tumor cells from hindlimb muscle into hematopoietic organs.

(A) H & E staining of bone, spleen and liver from recipients bearing primary myeloid tumor in the muscle, indicating aggressive infiltration of myeloid leukemia cells (60x) to distant anatomical locations. (B, C) Representative flow cytometry data demonstrating a similar immunophenotype of tumor cells in BM (B) and spleen (C) as that seen in the primary histiocytic sarcoma initiated in muscle (see Fig. 2D).