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. 2012 Aug 31;7(8):e44245. doi: 10.1371/journal.pone.0044245

Figure 3. Ex vivo susceptibility of multi-drug resistant strains of M.tb to trifluoperazine.

Figure 3

THP-1 cells and MDMs infected with M.tb at an MOI of 10∶1were treated with different concentrations (0, 1, 2.5 and 5 µg/ml) in duplicates as described in materials and methods. Post 1, 2 and 3 days of infection, cells were lysed and plated on 7H11 to enumerate CFUs. Graphs depict intracellular growth perturbation of (a) M.tbH37Rv in THP-1 cells, (b) M.tbJAL2287in THP-1 cells, (c) M.tb1934 in THP-1 cells, (d) M.tbH37Rv in MDMs and (e) M.tbJAL2287 in MDMs in presence of various concentrations of TFP. Values represent means ± standard errors of the means of duplicates.