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. 2012 Aug 31;7(8):e44656. doi: 10.1371/journal.pone.0044656

Figure 1. Synthetic Genetic Array Analysis of HMT1.

Figure 1

A) HMT1 genetic interaction network. Physical interactions between HMT1 and all of its genetic interactors identified from this study using the Synthetic Genetic Array methodology. The product of the gene identified is indicated within the relevant circle. The blue line represents a previously identified physical interaction. The complete genetic interaction network was created using Cytoscape, and the physical interaction data were obtained from the Saccharomyces Genome Database [55], [56]. B) GO terms for the Δhmt1 SGA interaction data set reveals enrichment for components of the Rpd3(L) complex [57]. Overrepresented GO terms and corresponding adjusted p-values were determined using FuncAssociate 2.0. GO term attributes are listed based on ascending adjusted p-values [40], [58].