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. 2012 Aug 31;7(8):e44393. doi: 10.1371/journal.pone.0044393

Table 2. Characteristics of and presentation material in advertisements promoting pharmaceuticals by year.

Content Year 2005 2006 2007 2008 2009
Advertisements Total number 535 560 641 468 432
Mean number of pages per advertisement 2.8 3 2.9 3.3 3.3
(SD) (1.4) (1.5) (1.8) (1.7) (1.6)
Minimum and maximum numbers of pages 1–9 1–10 0.5–11 0.25–11.0 0.25–7.0
Brief package insert information*, n (%) 475 (88.8) 508 (90.7) 529 (82.5) 416 (88.9) 385 (89.1)
Descriptiveexplanation Efficacy, n (%) 418 (78.1) 468 (83.6) 415 (64.7) 332 (70.9) 323 (74.8)
Safety, n (%) 471 (88.0) 511 (91.3) 551 (86.0) 400 (85.5) 379 (87.7)
Data in clinical trials orpost-marketing survey Efficacy and/or safety data, n (%) 64 (12.0) 102 (18.2) 353 (55.1) 321 (68.6) 318 (73.6)
Kaplan–Meier curve, n (%) 66 (12.3) 95 (17.0) 113 (17.6) 157 (33.6) 132 (30.6)
Differences from other agents (including placebo), n (%) 240 (44.9) 268 (47.9) 249 (38.9) 241 (51.5) 223 (51.6)
Backgroundpictures Real patient photograph, n (%) 46 (8.6) 25 (4.5) 11 (1.7) 7 (1.5) 13 (3.0)
Patient images, n (%) 206 (38.5) 219 (39.1) 258 (40.3) 133 (28.4) 109 (25.2)
Physician images, n (%) 1 (0.2) 6 (1.1) 30 (4.7) 20 (4.3) 36 (8.3)
Biological images, n (%) 171 (32.0) 174 (31.1) 90 (14.0) 24 (5.1) 22 (5.1)
Product photographs, n (%) 116 (21.7) 95 (17.0) 38 (5.9) 36 (7.7) 66 (15.3)
Animal photographs, n (%) 65 (12.2) 37 (6.6) 32 (5.0) 23 (4.9) 28 (6.5)
Illustrations representing efficacy, n (%) 54 (10.1) 34 (6.1) 117 (18.3) 106 (22.7) 156 (36.1)
*

Brief summary is extracted from approved package insert.