Table 3. Mass spectrometry results of retinal differential proteins between wide-type C57BL/6J, untreated rd12 and treated rd12 eyes at age P42.
Group ID | Protein | Acc.no. | Theoretical | No.of matched peptides | Coverage (%) | Protein Score | |
MW (kDa) | PI | ||||||
21 | peroxiredoxin 6 ↑ | gi|6671549 | 24.81 | 5.98 | 16 | 89.78 | 777 |
22 | crystallin, alpha A ↑ | gi|30794510 | 22.48 | 6.35 | 15 | 72.68 | 395 |
23 | crystallin, beta A4 ↑ | gi|10946672 | 22.45 | 5.9 | 13 | 78.39 | 586 |
24 | crystallin, beta A1 ↑ | gi|20304089 | 25.19 | 5.98 | 19 | 86.31 | 593 |
25 | crystallin, beta A1 ↑ | gi|20304089 | 25.19 | 5.98 | 15 | 79.92 | 570 |
26 | ribosomal protein, large P2 ↑ | gi|83745120 | 11.64 | 4.42 | 9 | 58.13 | 484 |
27 | Heat shock protein 70 ↑ | gi|42542422 | 70.83 | 5.28 | 33 | 79.74 | 674 |
28 | hypothetical protein LOC433182 ↑ | gi|70794816 | 47.11 | 6.37 | 29 | 59.92 | 726 |
29 | crystallin, beta A1 ↑ | gi|20304089 | 25.19 | 5.98 | 16 | 85.66 | 475 |
30 | eukaryotic translation elongation factor 1 delta isoform b ↑ | gi|54287684 | 31.27 | 4.96 | 11 | 30.94 | 212 |
31 | unnamed protein product ↑ | gi|26328639 | 17.82 | 9.41 | 11 | 61.51 | 409 |
32 | fascin homolog 1, actin bundling protein * | gi|113680348 | 54.47 | 6.44 | 26 | 35.72 | 321 |
33 | peroxiredoxin 6 * | gi|6671549 | 24.81 | 5.98 | 24 | 89.54 | 837 |
34 | modifier 2 ↑ | gi|53165 | 19.74 | 4.96 | 13 | 72.23 | 571 |
35 | alpha-A-crystallin ↑ | gi|387134 | 18.53 | 5.86 | 16 | 75.91 | 499 |
36 | L-lactate dehydrogenase B * | gi|6678674 | 36.55 | 5.7 | 13 | 52.44 | 311 |
37 | Spna2 protein * | gi|20380003 | 156.1 | 5.29 | 17 | 17.88 | 52 |
38 | Spna2 protein * | gi|20380003 | 156.1 | 5.29 | 45 | 43.65 | 259 |
39 | retinol binding protein 1, cellular * | gi|6755300 | 15.84 | 5.1 | 14 | 86.17 | 494 |
40 | RecName: Full = Inosine-5′- monophosphate dehydrogenase 1; Short = IMP dehydrogenase 1; AltName: Full = IM # | gi|1708472 | 55.26 | 6.29 | 23 | 56.13 | 541 |
41 | crystallin, beta A2 # | gi|10946978 | 22.22 | 6.3 | 12 | 73.53 | 617 |
42 | eukaryotic translation initiation factor 6 # | gi|27501448 | 26.49 | 4.63 | 5 | 22.4 | 264 |
Note: ↑: the protein is up-regulated in the untreated rd12 retinas; *: the protein is up-regulated in the treated rd12 retinas; #: the protein is up-regulated in the C57BL/6J retinas.