Table 3.
Multivariate Models for HF-ACTION Primary Endpoint (n=519 with complete data)
Multivariate Model | Multivariate Model Chi-Square Value | Multivariate p-value of added predictor(s) beyond the Basic model | C-index |
---|---|---|---|
Basic | 57.8 | 0.61 | |
Basic + Left ventricular diastolic dimension | 58.4 | 0.49 | 0.61 |
Basic + Left ventricular mass | 58.0 | 0.69 | 0.61 |
Basic + Left ventricular ejection fraction | 58.1 | 0.60 | 0.61 |
Basic + Left atrial dimension | 61.1 | 0.07 | 0.61 |
Basic + Peak mitral early diastolic-to-peak late diastolic velocity ratio | 66.6 | 0.003 | 0.62 |
Basic + Early diastolic deceleration time | 60.2 | 0.12 | 0.61 |
Basic + Peak mitral early diastolic velocity-to-tissue Doppler peak early diastolic myocardial velocity ratio | 65.6 | 0.005 | 0.61 |
Basic + Mitral regurgitation grade | 62.7 | 0.08 | 0.61 |
Basic + All 8 echo variables | 74.6 | multiple added predictors | 0.62 |
Basic + Peak oxygen consumption | 92.5 | <0.0001 | 0.64 |
Basic + Peak oxygen consumption + Peak mitral early diastolic-to-peak late diastolic velocity ratio | 94.8 | 0.13 (E/A) <0.0001 (peak VO2) | 0.64 |
Basic multivariate model for primary endpoint includes beta blocker dose (truncated at 50mg/day), body surface area, BUN, gender, KCCQ symptom stability score, region (U.S. vs. non-U.S.), ventricular conduction.