Table 4.

Univariate Predictors of HF-ACTION for Secondary Endpoint (Cardiovascular Disease Mortality or Heart Failure Hospitalization)

Echo Parameters	Sample Size	Hazard Ratio (95% confidence interval)	Chi-Square Value	p-value
Left ventricular diastolic dimension (cm)	1646	1.14 (1.06, 1.23)	12.7	0.0004
Left ventricular mass (per 100g)	1646	1.10 (1.04, 1.17)	10.8	0.001
Left ventricular ejection fraction (per 5%)	2327	0.82 ( 0.78, 0.87)	58.3	<0.0001
Left atrial dimension (cm)	1646	1.48 (1.33, 1.65)	49.7	<0.0001
Peak mitral early diastolic-to-peak late diastolic velocity ratio	1550	1.43 (1.33, 1.54)	71.2	<0.0001
Early diastolic deceleration time (per 50msec)	1604	0.83 (0.77, 0.89)	27.9	<0.0001
Tissue Doppler peak early diastolic myocardial velocity(cm/sec)	909	0.98 (0.95, 1.01)	2.24	0.13
Peak mitral early diastolic velocity-to-tissue Doppler peak early diastolic myocardial velocity ratio	796	1.23 (1.15, 1.33)	25.5	<0.0001
Mitral regurgitation grade(grades 0–4 vs. 5–6)	2135	2.3 (1.9, 2.8)	61.1	<0.0001
Peak oxygen consumption(ml/kg/min)	2275	0.86 (0.85, 0.88)	255.3	<0.0001